The CombiFlash® SFC from Teledyne LABS is an advanced purification system designed to make Supercritical Fluid Chromatography (SFC) as simple, accessible, and efficient as conventional flash chromatography. Combining the familiar operation of the CombiFlash platform with proven PeakTrak® software and the high-performance advantages of SFC, the system provides a seamless transition from normal-phase flash purification to faster and more efficient separations. Using carbon dioxide (CO₂) as the primary mobile phase, CombiFlash SFC enables rapid, high-performance purification while reducing organic solvent consumption by up to 95%. This helps laboratories lower solvent usage, reduce operating costs, and establish a more sustainable purification workflow. The system supports 40–200 mL/min flow rates and disposable flash columns ranging from 4 to 220 g. Four cosolvent options and gradients from 0–70% modifier composition provide flexibility for purifying a wide range of compounds. Integrated open-bed fraction collection, solid sample loading capabilities, and thermal management maintaining a consistent 40°C operating temperature further simplify day-to-day operation. With intuitive PeakTrak software and guided method-development tools, CombiFlash SFC enables chemists to utilize familiar silica stationary phases, column-selection strategies, and established flash chromatography workflows while gaining the speed, selectivity, and efficiency of SFC. CombiFlash SFC is ideally suited for pharmaceutical intermediates, medicinal chemistry compounds, natural products, specialty chemicals, synthetic reaction mixtures, and lipophilic compounds. Septech Marketing LLP, authorized distributor for Teledyne LABS, offers solutions and support for laboratories seeking faster, greener, and more productive purification technologies.