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Unique AutoOligo – Large Scale Oligonucleotide Synthesizer
Unique AutoOligo is a flexible, intuitive, and fully automated oligonucleotide synthesizer designed for rapid synthesis of 1 μmol to 50 mmol nucleic acid samples. It supports a wide range of applications including clinical research, pharmaceutical development, and molecular diagnostic probe synthesis.
With a high-precision metering pump drive system and advanced flow-through solid-phase column synthesis technology, Unique AutoOligo ensures efficient reagent usage, precise reaction control, and high synthesis throughput. The system is ideal for both method development and large-scale production, offering a scalable platform for nucleic acid manufacturing.
Model Synthesis Amount Range
Unique AutoOligo25 1–100 μmol
Unique AutoOligo100 50 μmol–9 mmol
Unique AutoOligo150 150 μmol–12 mmol
Unique AutoOligo600 1–50 mmol
Key Features:
High-Precision Metering Pump System:
*Accurate and stable reagent delivery
*Compatible with common nucleic acid synthesis reagents
*Excellent flow control and repeatability
Flow-Through Solid-Phase Column Synthesis:
*Reduces reagent consumption
*Ensures precise control of reaction speed and contact time
*Improves synthesis efficiency and yield
*Supports linear amplification workflows
Flexible Column Configuration:
*Optional multiple column positions
*Supports synthesis on 1, 3, or 8 columns simultaneously
*Simplifies workflow and increases throughput
High Automation & High Capacity:
*Fully automated synthesis process
*One synthesis cycle can be completed in as little as 20 minutes
*Supports sequential synthesis and method automation
Monomer Solution Recycling:
*Efficient reagent usage
*Reduces waste and cost
Advanced Monitoring & Control:
*Online UV monitoring
*Conductivity signal monitoring
*Pressure monitoring
*Real-time process control and safety
User-Friendly Software & Data Management:
*Intuitive interface for easy operation
*Flexible method editing
*Powerful data management system for method development
*Comprehensive traceability and batch recording
Regulatory Compliance:
*Designed to meet relevant FDA and USP requirements
*Suitable for regulated environments
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The ACCQPrep HP150 is a user-friendly preparative HPLC system designed to simplify purification workflows by eliminating unnecessary and complex method parameters commonly found in traditional HPLC systems. Built for efficiency and ease of use, it delivers high performance without requiring extensive training.
Key Features & Benefits
✅ Simplified Operation
Intuitive control via PeakTrak® software
Eliminates overly complex method setup
Designed specifically with chemists in mind
✅ Fully Integrated Software
Embedded system — no stand-alone PC required
Compact footprint with built-in touchscreen interface
Free software updates to adapt to evolving lab needs
✅ Smart Lab Monitoring
Active solvent level monitoring
Waste level detection to prevent overflow
Reduced risk of solvent spills and lab interruptions
✅ Intelligent Fraction Collection
RFID-enabled collection racks
Prevents missed or overfilled test tubes
Improves collection accuracy and efficiency
Designed for Modern Prep Labs:The ACCQPrep HP150 combines automation, safety features, and simplified controls into a compact preparative HPLC platform. It is ideal for laboratories seeking:
*Reliable compound purification
*Reduced operator error
*Streamlined workflows
*Compact, all-in-one HPLC systems
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Supercritical Fluid Chromatography (SFC) is an advanced separation technique that uses a supercritical fluid—most commonly carbon dioxide (CO₂)—as the mobile phase. In its supercritical state, CO₂ exhibits properties of both a gas (low viscosity, high diffusivity) and a liquid (solvation strength), enabling fast, efficient, and high-resolution separations.
SFC bridges the gap between gas chromatography (GC) and liquid chromatography (LC), offering the speed of GC with the versatility of LC.
How SFC Works
When CO₂ is brought above its critical temperature and pressure, it becomes a supercritical fluid. In this state, it:
Penetrates stationary phases efficiently (like a gas)
How SFC Works
When CO₂ is brought above its critical temperature and pressure, it becomes a supercritical fluid. In this state, it:
*Penetrates stationary phases efficiently (like a gas)
*Dissolves analytes effectively (like a liquid)
*Enables rapid mass transfer and shorter run times
Modifiers such as methanol or ethanol are often added to enhance solubility for polar compounds.
Dissolves analytes effectively (like a liquid)
Enables rapid mass transfer and shorter run times
Modifiers such as methanol or ethanol are often added to enhance solubility for polar compounds.
Key Components of an SFC System
An SFC system typically includes:
*Pump – Delivers liquid CO₂ and organic modifiers at precise flow rates
*Injector – Introduces the sample into the mobile phase
*Column oven – Maintains controlled temperature for reproducibility
*Chromatographic column – Packed with stationary phase for separation
*Detector – Commonly UV, PDA, MS, or ELSD for compound detection
*Back Pressure Regulator (BPR) – Maintains pressure to keep CO₂ in its supercritical state
Advantages of SFC:
✔ Faster separations compared to traditional HPLC
✔ High efficiency and sharp peak resolution
✔ Reduced solvent consumption (greener technology)
✔ Easy solvent removal due to volatile CO₂
✔ Ideal for chiral separations
✔ Compatible with mass spectrometry detection
Applications of SFC :SFC is widely used in:
*Pharmaceutical analysis – Chiral drug separation, impurity profiling
*Environmental testing – Pesticides and pollutant analysis
*Natural products research – Plant extracts and bioactive compounds
*Chemical research & synthesis labs – Reaction monitoring and purification
Why SFC is Growing in Popularity Supercritical Fluid Chromatography offers a powerful alternative to traditional HPLC by providing:
*Higher throughput
*Improved selectivity
*Lower operational costs
*Environmentally friendly workflows
As laboratories increasingly prioritize speed, sustainability, and analytical performance, SFC continues to gain adoption in both analytical and preparative-scale applications.
The PurIon™ Mass Spectrometer is a compact, affordable, single-quadrupole mass analyzer designed for mass-directed fractionation in flash and preparative purification labs. Built to integrate seamlessly with Teledyne ISCO purification systems, it enables chemists to instantly confirm compound identity during or prior to purification—without requiring specialized MS training.
Seamless Integration with Teledyne ISCO Systems PurIon interfaces directly with:
*CombiFlash NextGen
*CombiFlash EZ Prep
*ACCQPrep
Using PeakTrak® software, users benefit from:
*Single-point instrument control
*Three predefined ionization settings
*Customizable ionization parameters for signal optimization
*The Ion Finder utility to identify fragments and adducts
*Direct injection analysis prior to purification
Single Quadrupole Mass Analyzer- PurIon features a single-quadrupole mass analyzer with an atmospheric pressure interface optimized for chromatographic purification workflows.
Ionization Modes:
*Positive ion mode via proton attachment (M+H)+
*Negative ion mode via proton removal (M–H)–
This enables reliable molecular weight confirmation during purification or via direct injection.
Versatile and Reliable Performance
*Mass Selectivity: Easily isolate co-eluting peaks based on m/z
*Ionization Options:
Electrospray Ionization (ESI)
Atmospheric Pressure Chemical Ionization (APCI)
*Applications: Suitable for both normal-phase and reverse-phase chromatography
*Mass Range: Detect molecules from 10 Da up to 2000 Da
Model Options
“S“ Model
*Mass range: 10–1,200 Da (m/z)
*Interchangeable ESI or APCI source
*Automatic switching between positive and negative ion modes
*Includes fluid interface module for diverting a small sample stream to the MS
“L“ Model
*Mass range: 10–2,000 Da (m/z)
*Interchangeable ESI or APCI source
*Automatic positive/negative ion switching
*Includes fluid interface module
Why Choose PurIon?
*Affordable mass-directed purification
*Compact, lab-friendly design
*Minimal training required
*Reliable compound confirmation
*Flexible ionization and extended mass range
PurIon is ideal for chemists who need high-quality mass spectral data integrated directly into flash and prep purification workflows, without the complexity of high-end analytical MS systems.
For Enquiry Send Email Or Contact Septech Marketing LLP Now!