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Legacy Product Suggested Alternative Production End Date
Retriever 500 Foxy R1 Ended as of June 2018
Tris Pump PeriXus Ended as of January 2018
Base Model – PurIon Mass Spectrometer PurIon “S” Model Ended as of June 2018
CombiFlash RF 150 CombiFlash NextGen 300 Ended as of June 2018
CombiFlash RF+ CombiFlash NextGen 300+ Ended as of June 2018
CombiFlash RF+ PurIon CombiFlash NextGen 300+ PurIon Ended as of June 2018
Density Gradient Fractionation System None Ended as of January 2018
CombiFlash® Companion® CombiFlash NextGen 300 Ended as of December 31, 2008
CombiFlash® Companion® 4X CombiFlash NextGen 300+ Ended as of December 31, 2008
CombiFlash® Companion® XL CombiFlash Torrent Ended as of December 31, 2009
CombiFlash® RETRIEVE® CombiFlash NextGen 100 Ended as of December 31, 2009
CombiFlash® Optix® 10 System CombiFlash NextGen 300+ Ended as of December 31, 2009
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Unique AutoOligo – Large Scale Oligonucleotide Synthesizer
Unique AutoOligo is a flexible, intuitive, and fully automated oligonucleotide synthesizer designed for rapid synthesis of 1 μmol to 50 mmol nucleic acid samples. It supports a wide range of applications including clinical research, pharmaceutical development, and molecular diagnostic probe synthesis.
With a high-precision metering pump drive system and advanced flow-through solid-phase column synthesis technology, Unique AutoOligo ensures efficient reagent usage, precise reaction control, and high synthesis throughput. The system is ideal for both method development and large-scale production, offering a scalable platform for nucleic acid manufacturing.
Model Synthesis Amount Range
Unique AutoOligo25 1–100 μmol
Unique AutoOligo100 50 μmol–9 mmol
Unique AutoOligo150 150 μmol–12 mmol
Unique AutoOligo600 1–50 mmol
Key Features:
High-Precision Metering Pump System:
*Accurate and stable reagent delivery
*Compatible with common nucleic acid synthesis reagents
*Excellent flow control and repeatability
Flow-Through Solid-Phase Column Synthesis:
*Reduces reagent consumption
*Ensures precise control of reaction speed and contact time
*Improves synthesis efficiency and yield
*Supports linear amplification workflows
Flexible Column Configuration:
*Optional multiple column positions
*Supports synthesis on 1, 3, or 8 columns simultaneously
*Simplifies workflow and increases throughput
High Automation & High Capacity:
*Fully automated synthesis process
*One synthesis cycle can be completed in as little as 20 minutes
*Supports sequential synthesis and method automation
Monomer Solution Recycling:
*Efficient reagent usage
*Reduces waste and cost
Advanced Monitoring & Control:
*Online UV monitoring
*Conductivity signal monitoring
*Pressure monitoring
*Real-time process control and safety
User-Friendly Software & Data Management:
*Intuitive interface for easy operation
*Flexible method editing
*Powerful data management system for method development
*Comprehensive traceability and batch recording
Regulatory Compliance:
*Designed to meet relevant FDA and USP requirements
*Suitable for regulated environments
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Unique AutoPure – Protein Purification System
The Unique AutoPure Protein Purification System is designed for downstream purification in biopharmaceutical applications. It is widely used for the separation and purification of:
*Monoclonal antibodies (mAbs)
*Recombinant proteins
*Vaccines
*Biochemical drugs
*Antibiotics
*Natural products
*Polysaccharides
The system provides reliable, high-resolution chromatographic performance to support research, process development, pilot production, and GMP manufacturing environments.
Key Features & Advantages:
1. Modular Design & Flexible Configuration
*Modular platform architecture
*Multiple configuration options
*Customizable to meet specific process requirements
2. High-Precision Pump Technology
*Double plunger infusion pump
*Multiple patented technologies
*Stable flow rate and gradient control
*Excellent separation reproducibility
3. Biocompatible & Regulatory-Compliant Materials
*All wetted parts made of biocompatible materials
*Compliant with FDA, USP Class VI, and relevant regulatory requirements
*Suitable for GMP environments
4. Advanced Detection System
DAD Full-Spectrum Detector
*Direct spectral reading
*Eliminates instability and high failure rate associated with traditional mechanical grating detectors
Fixed Wavelength UV Detector
*Long-life LED lamp (service life > 8000 hours)
*Reduced maintenance cost
*Stable signal output
Patented UV Detector Flow Cell
*Low dead volume
*Minimal peak broadening
*Improved chromatographic resolution
High-Sensitivity Online Monitoring
*pH detection
*Conductivity detection
*UV monitoring
*Low dead volume design to enhance resolution
5. High Level of Automation
*Centralized automatic buffer selection valve
*Automatic sampling valve
*Column position valve
*Improved purification efficiency and automation
6. Comprehensive Safety Protection
*Pre-column and post-column pressure monitoring
*Differential pressure alarm
*Bubble sensor detection
*Enhanced protection for chromatography columns and system components
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The Unique AutoPure Pilot600 is a benchtop chromatography system designed for pilot-scale process development and small-scale GMP production. Available in both GMP and non-GMP configurations, the system provides flexibility, precision, and scalability to support biopharmaceutical purification processes.
With a wide operating flow range, high pressure tolerance, and comprehensive detection capabilities, the AutoPure Pilot600 meets the demands of process scale-up, pilot production, and early-stage commercial manufacturing.
System Overview:The Unique AutoPure Pilot600 offers flexible configuration options and supports chromatography columns ranging from 26 mm to 200 mm in diameter, making it suitable for small-scale, pilot-scale, and limited production applications.
Key Features
1. Compact & User-Friendly Design
*Benchtop, compact structure for easy movement
*All functional components conveniently located on the front panel
*Simplified operation and maintenance
2. High-Performance Pump System
*High-precision, large-flow plunger pumps
*Stable flow rate and accurate gradient formation
*Suitable for small-scale, pilot-scale, and small GMP production processes
3. Advanced Detection System
*Fixed or variable wavelength UV detector
*Conductivity detector
*pH detector
*Real-time monitoring and recording of process parameters
4. Regulatory Compliance
*Software with audit trail functionality
*User access management
*Electronic signatures (e-signature)
*Data analysis and report generation
*Designed to meet FDA 21 CFR Part 11 requirements
Control System:The AutoPure Pilot600 is powered by the Unique CDSystem Chromatography Workstation, equipped with a branded computer and intuitive user interface.
Intelligent System Control
*Real-time online monitoring and control
*Visual flow diagram interface
*Intuitive operation with integrated shortcut commands
*Simplified method editing and intelligent programming
*Comprehensive data management and traceability
The visual process flow interface makes every operation clearly visible, improving operational efficiency and reducing user error.
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Unique AutoTFF075 Crossflow Filtration System
The Unique AutoTFF075 is a flexible, automated laboratory-scale crossflow filtration (TFF) system designed for concentration, diafiltration, and clarification applications. The system is compatible with both hollow fiber membranes and cassette filters, providing versatile solutions for a wide range of bioprocessing needs.
It is widely used in the processing and purification of biological products, including:
*Monoclonal antibodies (mAbs)
*Recombinant proteins
*mRNA and other nucleic acids
*Viral vectors
*Gene therapy products
Its flexible configuration supports both manual operation and fully automated process control. When combined with a comprehensive data management system, the AutoTFF075 is ideal for:
*Small-scale process development
*Process scale-up studies
*Formulation optimization
*Sample preparation
Key Features:
1. Automated TMP & Process Control
*Automatic transmembrane pressure (TMP) control
*Integrated weighing and feeding modules
*Precise control of concentration ratio
*Accurate diafiltration volume management
2. Compact & Efficient Design
*Small recirculation volume
*Optimized for high-concentration applications
*Space-saving laboratory footprint
3. User-Friendly Control Software
*Easy recipe setup
*Real-time operation control
*Data recording and traceability
*User access management
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4. Optional Permeate Pump
*Enhanced microfiltration process control
*Improved flux regulation
*Greater operational flexibility
5. High Level of Automation
*Pre-defined method modules
*Programmable recipes and recipe sequences
*Reduced operator variability
6. Comprehensive Process Monitoring (Optional)
*Conductivity sensor
*8pH monitoring
*UV detection
*Real-time analytical integration
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7. Broad Membrane Compatibility
*Supports various cassette filter formats
*Compatible with multiple hollow fiber systems
The Unique AutoMCD™ is an advanced automated system designed for the precise assembly of nanoparticles, including LNPs (Lipid Nanoparticles), liposomes, polymer-based nanoparticles, PLGA particles, and other nano-formulations.
It is widely applied in the production of mRNA and oligonucleotide-based therapeutics, enabling consistent, scalable, and high-quality nanoparticle manufacturing.
With highly accurate and stable flow rate and pressure control, combined with tailored microfluidic mixing technology, the system ensures optimal control over particle size, polydispersity index (PDI), and encapsulation efficiency—critical parameters for nucleic acid drug delivery.
Key Features:-
1. Patented Metered Liquid Delivery Technology:
*Low pulsation flow control
*Excellent particle size uniformity
*High reproducibility between batches
2. Hygienic Pump Design (CIP-Compatible):
*Supports Cleaning-In-Place (CIP)
*Minimizes cross-contamination risk
*Suitable for GMP environments
3. Pressure-Assisted Mixing Technology:
*Ensures low PDI
*Achieves high encapsulation efficiency
*Improves nanoparticle stability and consistency
4. Scalable System Architecture:
*Multiple system scales available (R&D to production)
*Interchangeable mixing cartridges
*Seamless scale-up capability
5. Regulatory Compliance:
*Designed to meet GMP requirements
*Compliant with FDA 21 CFR Part 11 standards
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The Unique AutoPrep Preparative HPLC system is a high-performance solution designed for the efficient separation and purification of small molecules, natural products, and pharmaceutical compounds. Built for reliability and precision, the AutoPrep series delivers consistent, high-purity results across both low-throughput daily workflows and demanding high-throughput purification applications.
With its advanced automation and intelligent control software, the Unique AutoPrep system simplifies complex preparative tasks, enabling users to process valuable and intricate mixtures with high recovery, exceptional purity, and complete confidence in reproducibility.
Key Features
Advanced Automation for Seamless Purification
The Unique AutoPrep system is comprised of:
*Injector
*Preparative Chromatography Host
*Preparative Chromatography Column
*Fraction Collector
The system automatically performs all essential operations including:
✔ Sample injection
✔ Separation and purification
✔ Collection of target fractions
Intuitive Control with Unique CDSYSTEM Software: The integrated Unique CDSYSTEM chromatography workstation provides comprehensive functionality, including:
*Instrument control
*Purification method development
*Automated operation
*Automatic injection and fraction collection
*Data acquisition, storage, and management
Flexible Configuration Options : Choose the configuration that best fits your workflow:
*Binary High-Pressure Gradient
*Binary Low-Pressure Gradient
8Quaternary Low-Pressure Gradient
*Isocratic Pump
Configurable Differential Detector:Supports flexible detector configuration to meet various analytical needs and sensitivity requirements.
Dynamic Mixer with Flexible Flow Range:The system supports multiple dynamic mixer specifications, allowing quick replacement of mixing chambers to accommodate different flow rate ranges and ensure optimal mixing performance.
Superior Performance & Reliability :The Unique AutoPrep system delivers:
*High flow rate accuracy and precision
*Excellent component accuracy
*Outstanding gradient linearity
Advanced Stability and Noise Reduction:
*Pressure fluctuation compensation reduces system noise and enhances reproducibility
*Dual-beam compensation technology provides high stability and low baseline drift
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Teledyne ISCO SyriXus® single-pump systems combine a precision pump module with a versatile controller to deliver reliable, high-performance fluid metering for a wide range of applications.
Pump Module:The piston-driven pump module features a single-speed gear train for consistent, repeatable operation. Nitronic 50 is used as the standard material for cylinders, pistons, and caps, offering excellent durability and chemical resistance. For even more demanding environments, Hastelloy and other alloy options are available.
Standard seals are graphite-impregnated Teflon, providing long life even under harsh conditions. Optional seal materials are also available to meet specialized application requirements.
The SyriXus controller supports multiple operating modes and advanced features, and the software can be customized to your specific application upon request.
Standard operating modes include:
Constant Flow
Constant Pressure
Flow or Pressure Programming
External Control
Enquiry Mode
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The Teledyne ISCO ReaXus Series offers a versatile range of reciprocating pumps designed to meet a wide variety of laboratory and industrial needs. With flow rates spanning 5 mL/min to 300 mL/min and pressures up to 6,000 psi, the ReaXus line delivers reliable performance across demanding applications.
Whether your priority is low pulsation, handling hazardous materials, or maintaining consistent flow, there is a ReaXus pump configuration that fits your requirements. The single-piston models are optimized for material transfer and pressure generation, while the dual-piston models are designed for continuous processing applications where steady, uninterrupted flow is critical.
ReaXus pumps are also engineered for low maintenance and long-term reliability. Unlike many other pump technologies, ReaXus pumps require no calibration, helping reduce downtime and lower operational costs.
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The Teledyne ISCO PeriXus Peristaltic Pump is designed for both laboratory use and continuous processing applications. Its compact, modular footprint makes it ideal for space-constrained environments, while proven peristaltic pumping technology minimizes the risk of cross-contamination—making it especially well suited for handling volatile, sensitive, or high-purity materials.
Quick-change hose capability allows operators to switch between materials in minutes, maximizing productivity and application flexibility. A wide selection of hose options is available to accommodate demanding applications, including highly viscous fluids.
With a broad flow rate range from 0.005 to 162 mL/min, the PeriXus pump supports a wide variety of laboratory and industrial processes across multiple markets, including:
*Pharmaceutical and Biotechnology
*Research and Development
*Petrochemical Processing
*Reaction Chemistry
Key Specifications:
*Speed (RPM): 0.1 to 300
*Flow Range: 0.05 to 162 mL/min (L/S 16 tubing)
*Speed Control Repeatability: ±0.1%
*Motor: Reversible
*IP Rating: IP33
*Dimensions: 9.4 × 5.5 × 6.2 in (23.9 × 14.0 × 15.7 cm)
*Power: 90–260 VAC, 50/60 Hz
*Current Draw: 0.34 A at 115 VAC; 0.2 A at 230 VAC
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Teledyne ISCO SyriXus dual-pump continuous-flow systems are designed to deliver a smooth, uninterrupted flow of fluid for demanding laboratory and industrial applications. By coupling two pump modules to a single controller and integrating an active or passive valve manifold, these systems provide true non-stop, continuous fluid delivery for nearly any fluid type.
During operation, the controller intelligently refills one pump while the other is dispensing. Advanced control algorithms continuously balance pressure and flow between the two pumps, enabling virtually pulseless pump switchover while maintaining precise and consistent flow rates. The result is reliable, highly accurate continuous flow without interruptions or pressure fluctuations.
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Teledyne ISCO HLF-Series precision syringe pumps are engineered to deliver accurate, predictable flow and pressure control across an exceptionally wide operating range. Designed for use in hazardous and demanding environments, these pumps provide smooth, pulsation-free performance, eliminating the flow irregularities commonly associated with other pump technologies.
HLF-Series pumps are purpose-built to meter a broad variety of challenging fluids with exceptional accuracy, including aqueous and organic liquids, corrosive solutions, heated fluids, liquefied gases, viscous materials, slurries, and pastes. Their robust design ensures reliable operation even under extreme process conditions.
Extensive Chemical Compatibility:The wetted materials used in HLF-Series pumps have been rigorously tested for compatibility with a wide range of industrial and laboratory chemicals, including:
Acetone, acetonitrile, ammonia, benzene, butadiene, butane, diesel fuel, ethane, ethylene, ethylbenzene, gasoline, heptane, hexane, isobutylene, isopropanol, jet fuel, methane, methanol, propane, and propylene.
This broad chemical compatibility makes the HLF-Series an ideal solution for chemical processing, petrochemical, energy, and laboratory applications.
Advanced Multi-Pump Control:The HLF controller can operate up to four pumps simultaneously, enabling efficient control of complex pumping systems. A user-friendly keypad and LCD display provide intuitive local operation, while built-in and optional communication interfaces support seamless integration with computers and external devices.
Flexible and efficient programming allows **instant access to menu screens—even while the pump is running—**so operating parameters can be adjusted in real time without interrupting the process. For added installation flexibility, an optional remote extension cable allows the pump to be positioned up to 50 feet (15 meters) from the controller.
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